Unique properties of botulinum toxins.
نویسندگان
چکیده
This session of the TOXINS2008 conference was organized with the aim to provide an open forum in which similarities and differences between the various botulinum toxin (BoNT) preparations are highlighted and discussed. To this end the organizers invited representatives of the manufactures of the four commercially available BoNT products, Botox, Dysport, Xeomin, Myobloc/Neurobloc, to briefly summarize what unique properties they believe differentiate their products from the other products. After a full disclosure of relationships to the pharmaceutical company, each presenter was allowed an equal opportunity and the same amount of time (25 min) to state his case. Each presentation was followed by questions and answers from the audience, after which time the representatives were given an opportunity to ask each other questions. After the congress each presenter was provided with the transcript of presentations and of the general discussion and was asked to edit the presentation, but not to expand the content beyond what they presented during the session. The presenters were also allowed to cite not more than 5 peer-reviewed references to supplement their presentations and to provide 3 figures from their slide presentations. Despite these guidelines, which were intended to provide as much fairness as possible, the audience and the reader should understand and the organizers fully acknowledge that the presentations were probably biased
منابع مشابه
Dual toxin-producing strain of Clostridium botulinum type Bf isolated from a California patient with infant botulism.
A retrospective study of Clostridium botulinum strains isolated from patients from California with infant botulism identified the fourth known C. botulinum strain that produces both type B and type F botulinum toxins. This unique strain represented 0.12% of the California infant botulism case isolates from 1976 to 2003. The relative concentrations of type B and F toxins produced were temperatur...
متن کاملReview Diffusion of Botulinum Toxins
Background: It is generally agreed that diffusion of botulinum toxin occurs, but the extent of the spread and its clinical importance are disputed. Many factors have been suggested to play a role but which have the most clinical relevance is a subject of much discussion. Methods: This review discusses the variables affecting diffusion, including protein composition and molecular size as well as...
متن کاملDiscussion of unique properties of botulinum toxins.
, A., Discussion of unique Acomment aboutAndyPickett’s slides,which attempted to show similarity to the Diane Tang-Liu and Roger Aoki paper (Tang-Liu et al., 2003). In the first two papers, those were saturateddoses, and theywereperformed fordifferent purposes and cannot really be used in the way Andy Pickett used them. The other issue is on the definitions. I think now we are all very confused...
متن کاملDiffusion of Botulinum Toxins
BACKGROUND It is generally agreed that diffusion of botulinum toxin occurs, but the extent of the spread and its clinical importance are disputed. Many factors have been suggested to play a role but which have the most clinical relevance is a subject of much discussion. METHODS This review discusses the variables affecting diffusion, including protein composition and molecular size as well as...
متن کاملBotulinum toxins in neurological disease.
Botulinum toxins are among the most potent neurotoxins known to humans. In the past 25 years, botulinum toxin has emerged as both a potential weapon of bioterrorism and as a powerful therapeutic agent, with growing applications in neurological and non-neurological disease. Botulinum toxin is unique in its ability to target peripheral cholinergic neurons, preventing the release of acetylcholine ...
متن کاملMass Spectrometric Detection of Bacterial Protein Toxins and Their Enzymatic Activity
Mass spectrometry has recently become a powerful technique for bacterial identification. Mass spectrometry approaches generally rely upon introduction of the bacteria into a matrix-assisted laser-desorption time-of-flight (MALDI-TOF) mass spectrometer with mass spectrometric recognition of proteins specific to that organism that form a reliable fingerprint. With some bacteria, such as Bacillus ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- Toxicon : official journal of the International Society on Toxinology
دوره 54 5 شماره
صفحات -
تاریخ انتشار 2009